PHARMACEUTICAL CHEMISTRY SYLLABUS

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PHARMACEUTICAL CHEMISTRY – PY 603  SYLLABUS

( I ) Classification and mode of action,uses,structure activity relationship including physico chemical, steric aspects and recent advances in research of the followingb categories of drugs:
(A) Drug Acting on CNS

•  General Anesthetics: Stages of Anesthesia , Pharmacokinetic Principles, Theories of the mechanisms.

•  Hypnotics and Sedatives : Testing and developments of new Hypnotics.

•  Antiscizure agents: Drugs effective against partial and generalized tonicclonic scizure.

•  Opiod Analgesics : Endogenous opioid peptides and their physiologic functions, Neurobiology of drug abuse and addiction.

•  Antiparkinsonian and Spasmolytic agents : Pharmacotherpy of Parkinsonsdisease.

•  Hallucinogens, Stimulants, and related drugs of Abuse.

•  Psychopharmacological Agents: Antipsychotic agents, Antidepressants,Anxiolytics.

(B) Drug Acting on GIT :

•  Laxative

• Antimalarial

•  Anti spasmodic

•  Anti ulcers Drugs.

(C) Drug Acting on Hormonal System:

•  Insulin and oral Hypoglycemic agents: Etiology of Diabetes, Biochemistry and Pathogenesis of Diabetes, Production of Insulin.

•  Adrenocorticoids: Mechanism of steroid Hormone action, Development of Adrenocorticoid drugs.

• Sex Hormones: Male sex Hormones, Female sex Hormones.

• Thyroid and Antithyroid agents : Biochemistry and Physiology of Thyroid Hormones, Biosynthesis of Thyroid Hormones.

(D) Vitamins

  
( II )Principles of Drug Design (Theoretical Aspects).Scientific Aspects of Drug Discovery, Preclinical Development, Mechanism based Approaches (Computer Aided Drug Design and Molecular Modeling)

BOOKS RECOMMENDED:

• Foye, W.C., Principles of Medicinal Chemistry, Lea and Febiger, Philadelphia.

• Wolff , M.E. Ed., Burger’s Medicinal Chemistry, John Wiley and Sons,New York.

• Hansch, C., Comprehensive Medicinal Chemistry, Pergarnon Press,Oxford.

• Delagado, J.N. and Remers, W.A.R, Wilson and Giswold’s Text Book of Organic,Medicinal and Pharmaceutical Chemistry, J.Lippincott Co.,Philadelphia.

• Nogrady, T., Medicinal Chemistry-A Biochemical Approach, Oxford University Press, New York, Oxford.

• Kar, A., Medicinal Chemistry, Willey Eastern Ltd., New Delhi.

• Patrick, G., An Introduction to Medicinal Chemistry, Scientific Distributors, Mumbai.

• Malone, Dyson and Purey, May’s Chemistry of Synthetic Drugs.

• Parimoo, P., Text Book of Medicinal Chemistry, CBS Publishers and Distributors, New Delhi.

• Thomas, G., Introduction to Medicinal Chemistry, CBS Publishers and Distributors, New Delhi.

LIST OF PRACTICALS :

• Synthesis and Characterization of Methylphenobarbital from Urea.

• Synthesis and Characterization of Barbital from Urea.

• Synthesis and Characterization of Nikethamide from Nicotinic acid.

• Synthesis and Characterization of Pantaprazol.

• Synthesis and Characterization of Diclofenamide.

• Synthesis and Characterization of Phenobarbitone.

• Synthesis and Characterization of Phenothiazine.

• Synthesis and Characterization of Furosemide from 2,4 dichloro-benzoic acid.

• Synthesis and Characterization of Levodopa from Vanillin.

• Synthesis and Characterization of Sulfalene from p-aminobenzene sulphonyl chloride.

• Synthesis and Characterization of Thioridazine.

• Synthesis and Characterization of Chlorpromazine.

• Synthesis and Characterization of Benorilate.

• Synthesis and Characterization of Parbanic acid.

• Estimation of Na+, K+, Ca++ ions using flame photometry.

• To perform the QSAR Analysis by Free Wilson Approach.

• To determine the regression coefficients for a series by using Hansch and Free Wilson Approach.

• To determine the correlation between physiochemical properties and biological activity for a series by using Hansch analysis.