BIOPHARMACEUTICS AND PHARMACOKINETICS PY-802 SYLLABUS

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BIOPHARMACEUTICS & PHARMACOKINETICS PY-802 SYLLABUS

UNIT-I

Introduction:biopharmaceutics and pharmacokinetics development and their role in drug formulation.Biopharmaceutics

UNIT-II

Definition:passage of drugs across biological barrier,Physio chemical,Biological and Pharmaceutical factors influencing biopharmaceutical performance of drugs.
1.Gastrointestinal absorption of drugs: Passage of drugs across biological membranes, nature of biological membranes, gastrointestinal absorption mechanisms.
2. Factors affecting drug absorption: Physiological factors, dietary factors, physicochemical factors, pH partition hypothesis, dosage form factors.
3. Methods of studying gastrointestinal absorption: In vitro and in vivo methods.
4. Drug disposition: Distribution in blood, cellular distribution, plasma protein binding, tissue protein binding.Drug Excretion: Routes of drug excretion, renal excretion of drugs, factors affecting renal excretion, biliary and salivary excretionof drugs.

UNIT-III

Drug bio transformation:Pathways of drug metabolism, drug metabolizing enzymes, factors affecting drug metabolism and drugresponse, inhibition and stimulation of drug metabolism.
Pharmacologist,distribution,metabolism & excretion of drugs,fluid compartment and circulatory system, protien binding,significance of plasma drug concentration measurement .Compartment Models

UNIT-IV

Model selection criteria:alaika information criterion, one-compartment and two-compartment models, Wagner-Nelson and looRiegelman methods for estimation of absorption constants. Curve fittings,regression procedure and area under blood level curves.Clinical Pharmaco-kinetics.Urinary excretions, computation of pharmacokinetic parameters from urine data, haepetic clearance, biliary excretion, excretion ratio, dosage regimen adjustment in patients with and without renal failure, pharmacokinetic drug interactions and theirsignificance in combination therapy.

UNIT-V 
Bio availability & Equivalence:Bioavailability and Bio-equivalence,Federal requirements , Methods of determination of bioavailability using blood level and urinary excretion data, design and evaluations, bioavailability assessment.

PRACTICALS LIST

Experiments based on theory.Statistical treatment of pharmaceutical data.

BOOKS RECOMMENDED

• Gibaldi, M. and Perrier d, Pharmacokinetics, Marcel Decker, New York.

• Notari, R.E., Biopharmaceutics and Pharmacokinetics-An Introduction, Marcel Decker, New York.

• Jaiswal , Brahmankar

PHARMACEUTICS –XI PY-801 SYLLABUS

META TAGS:-RGPV B. PHARMACY 8TH SEM SYLLABUS I RGPV B. PHARMACY 8TH SEM SYLLABUS FOR PHARMACEUTICS SYLLABUS I PHARMACEUTICS TECHNOLOGY II SYLLABUS I RGPV  B. PHARMACY 8TH SEM SYLLABUS DOWNLOAD I PHARMACEUTICS –XI SYLLABUS I RGPV B.PHARMACY 8TH SEM SYLLABUS I RGPV BHOPAL B.PHARMACY 8TH SEM SYLLABUS I DOWNLOAD RGPV 8TH SEM SYLLABUS I DOWNLOAD B. PHARMACY 8TH SEM SYLLABUS I B.PHARMACY SYLLABUS I DOWNLOAD B.PHARMACY EXAM PAPERS I B.PHARMACY 8TH SEM GUESS PAPERS I RGPV B.PHARMCY 8TH SEMESTER SYLLABUS I DOWNLOAD RGPV B.PHARMACY 8TH SEM COMPLETE SYLLABUS I DOWNLOAD RGPV B.PHARMACY COMPLETE SYLLABUS I B.PHARMACY ALL SEMESTER

PHARMACEUTICS –XI (PHARMACEUTICAL TECHNOLOGY – II) PY-801 SYLLABUS

UNIT-I

Design, development, formulation and evaluation of controlled release formulations. Carriers for drug delivery systems, Pro drugs.

UNIT-II

Micro encapsulation: Theory, methods, technology and applications.

UNIT-III
Trans dermal Drug Delivery Systems: Theory, formulation and evaluation.

UNIT-IV

Targeted Drug Delivery Systems: Concept of drug targeting, importance in therapeutics, methods in drug targeting, Nano particles, Lithesome, Resealed Erythrocytes etc.

UNIT-V

Implants and Inserts:Types,design and evaluation,Osmotic pump.Packaging of Pharmaceutical Products and Cosmetics: Packaging components, types, specifications and methods of evaluation,stability aspects of packaging, packaging equipment, factors influencing choice of containers, legal and other official requirements for containers, Packaging testing.

PRACTICAL LIST:-
Formulations, evaluations and stability testing of preparations concerning dosage forms mentioned in theory.

BOOKS RECOMMENDED:

• Rawlins, E.A., Text Book Of Pharmaceutics, Bailliere Tindall.

• Lachman, L. Liberman, H.A. and Kanig, J.L.,The Theory and Practice of Industrial Pharmacy, Lea and Febiger, Philadelphia.

• Liberman, H.A., lachman, L. and Ker Inc. New York.

• Pharmacopoeia Of India, Ministry of Health and family Welfare, Govt. of India, New Delhi.

• Avis, K.E., Lachman, L. and Liberman, H.A., Pharmaceutical Dosage Forms-Parenteral Medication Vol.1-2, Marcel Decker Inc., New York.

• Banker G.S. and Rhode C.T., Modern Pharmaceutics, Marcell Decker Inc., New York.

• Bean, H.S., Beckeet, A.H. and Carless, A.H., Advances in Pharmaceutical Sciences, Vol.1-4, Academic Press, London.