RGPV CS VIII SEMESTER BIOINFORMATICS (CS-8301) SYLLABUS
Unit-I
Introduction:Introduction to bioinformatics,objectives of bioinformatics,Basic chemistry of nucleic acids,structure of DNA & RNA,Genes,structure of bacterial chromosome,Cloning methodology, Data maintenance and Integrity Tasks.Unit-II
Bioinformatics Databases & Image Processing:Types of databases,Nucleotide sequence databases,Protein sequence databases,Protein structure databases,Normalization,Data cleaning and transformation,Protein folding,protein function,proteinpurification and characterization,Introduction to Java clients,CORBA,Using MYSQL,Feature Extraction.
Unit-III
Sequence Alignment and database searching:Introduction to sequence analysis,Models for sequence analysis,Methods of optimal alignment, Tools for sequence alignment,Dynamics Programming,Heuristic Methods,Multiple sequence Alignment
Unit-IV
Gene Finding and Expression:Cracking the Genome,Biological decoder ring,finding genes through mathematics & learning,Genes prediction tools,Gene Mapping,Application of Mapping,Modes of Gene Expression data,Mining the Gene Expression Data
Unit-V
Proteomics & Problem solving in Bioinformatics:Proteome analysis,tools for proteome analysis,Genetic networks,Network properties and analysis,complete pathway simulation: E-cell,Genomic analysis for DNA & Protein sequences,Strategies and options for similarity search,flowcharts for protein structure prediction .
Reference Books:
- Gopal & Jones, BIOINFORMATICS with fundamentals of Genomics & Proteomics ,TMH Pub
- Rastogi ,Bioinformatics –Concepts, skills & Applications ,CBS Pub
- Bergeron ,Bioinformatics computing ,PHI
- Claverie ,Bioinformatics , Wiley pub
- Baxevanis , Bioinformatics , Wiley Pub
- Stekel , Micrarray BioInformatics , Cambridge
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